Assay Detail
Functional
CHEMBL4713837
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Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 1,3,6,7-tetrahydroxyxanthone derivatives as phosphoglycerate mutase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.76 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260553 | — | — | 1 | 5.66 |
| CHEMBL4775985 | — | — | 1 | 5.47 |
| CHEMBL4748271 | — | — | 1 | 4.87 |
| CHEMBL3335789 | — | — | 1 | 4.58 |
| CHEMBL4796535 | — | — | 1 | 4.55 |
| CHEMBL4776823 | — | — | 1 | 4.38 |
| CHEMBL519864 | — | — | 1 | 4.32 |
| CHEMBL4783891 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260553 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4775985 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4748271 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3335789 | — | EC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4796535 | — | EC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL4776823 | — | EC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL519864 | — | EC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL4783891 | — | EC50 | = | 60000.0 | nM | 4.22 |