Assay Detail
Binding
CHEMBL4714039
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Binding affinity to HSP90-alpha (unknown origin) expressed in Escherichia coli BL21 by SPR assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 7 | - | - |
| Kd | 4 | 6.02 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741221 | — | — | 1 | 7.20 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.05 |
| CHEMBL4778213 | — | — | 1 | 5.51 |
| CHEMBL4777557 | — | — | 1 | 5.32 |
| CHEMBL4793820 | — | — | 1 | - |
| CHEMBL4763237 | — | — | 1 | - |
| CHEMBL4760618 | — | — | 1 | - |
| CHEMBL4778010 | — | — | 1 | - |
| CHEMBL1549420 | — | — | 1 | - |
| CHEMBL1650269 | — | — | 1 | - |
| CHEMBL528463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741221 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL109480 | TANESPIMYCIN | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL4778213 | — | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL4777557 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL4793820 | — | Activity | - | — | - | |
| CHEMBL4763237 | — | Activity | - | — | - | |
| CHEMBL4760618 | — | Activity | - | — | - | |
| CHEMBL4778010 | — | Activity | - | — | - | |
| CHEMBL1549420 | — | Activity | - | — | - | |
| CHEMBL1650269 | — | Activity | - | — | - | |
| CHEMBL528463 | — | Activity | - | — | - |