Assay Detail
Binding
CHEMBL4714060
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Inhibition of HSP90-alpha (unknown origin) expressed in Escherichia coli BL21 assessed as reduction in ATPase activity in presence of PEP, NADH and ATP by pyruvate kinase/lactic dehydrogenase based coupled enzyme assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.64 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741221 | — | — | 1 | 6.80 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.07 |
| CHEMBL4777111 | — | — | 1 | 5.89 |
| CHEMBL4748845 | — | — | 1 | 5.77 |
| CHEMBL4759116 | — | — | 1 | 5.57 |
| CHEMBL4777925 | — | — | 1 | 5.30 |
| CHEMBL4777557 | — | — | 1 | 5.25 |
| CHEMBL4778213 | — | — | 1 | 5.21 |
| CHEMBL4745924 | — | — | 1 | 4.86 |
| CHEMBL4746322 | — | — | 1 | - |
| CHEMBL4760861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741221 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4777111 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4748845 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4759116 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4777925 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4777557 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4778213 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4745924 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4746322 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4760861 | — | IC50 | > | 40000.0 | nM | - |