Assay Detail
Functional
CHEMBL4714136
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Growth inhibition of human UKE-1 cells incubated for 72 hrs by Cell-titer blue assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UKE-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.20 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 7.00 |
| CHEMBL4744236 | — | — | 1 | 6.82 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 6.72 |
| CHEMBL4785050 | — | — | 1 | 6.70 |
| CHEMBL4762807 | — | — | 1 | 6.68 |
| CHEMBL4760892 | — | — | 1 | 6.50 |
| CHEMBL2002099 | — | — | 1 | 6.42 |
| CHEMBL4745155 | — | — | 1 | 6.21 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 6.18 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.04 |
| CHEMBL1287854 | — | — | 1 | 5.98 |
| CHEMBL4788363 | — | — | 1 | 5.66 |
| CHEMBL4750568 | — | — | 1 | 5.50 |
| CHEMBL4753959 | — | — | 1 | 5.35 |
| CHEMBL4743499 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4744236 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4785050 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4762807 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4760892 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2002099 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4745155 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL1287854 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4788363 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4750568 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4753959 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4743499 | — | IC50 | = | 6300.0 | nM | 5.20 |