Assay Detail
Binding
CHEMBL4714259
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Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.46 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782814 | — | — | 1 | 8.40 |
| CHEMBL4747591 | — | — | 1 | 7.77 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 6.20 |
| CHEMBL4085457 | RITLECITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782814 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4747591 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4085457 | RITLECITINIB | IC50 | > | 10000.0 | nM | - |