Assay Detail
Binding
CHEMBL4714385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAOB using kynuramine as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.64 |
| CHEMBL4786674 | — | — | 1 | 5.81 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.71 |
| CHEMBL4792421 | — | — | 1 | 5.23 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4786674 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4792421 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 14190.0 | nM | 4.85 |