Assay Detail
Binding
CHEMBL4714422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of microtubule depolymerization in rat A10 cells incubated for over night by immunofluorescence method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | A10 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.40 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753899 | — | — | 1 | 8.72 |
| CHEMBL516047 | — | — | 1 | 8.70 |
| CHEMBL444724 | — | — | 1 | 8.70 |
| CHEMBL2420867 | — | — | 1 | 8.70 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.68 |
| CHEMBL4746488 | — | — | 1 | 8.62 |
| CHEMBL4748714 | — | — | 1 | 8.57 |
| CHEMBL2420866 | — | — | 1 | 8.52 |
| CHEMBL512022 | — | — | 1 | 8.09 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.01 |
| CHEMBL4756669 | — | — | 1 | 7.91 |
| CHEMBL3604205 | — | — | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753899 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL516047 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL444724 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2420867 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL492399 | VERUBULIN | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4746488 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4748714 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2420866 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL512022 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL67 | COMBRETASTATIN A4 | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4756669 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3604205 | — | EC50 | = | 23.4 | nM | 7.63 |