Assay Detail
Functional
CHEMBL4714424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.57 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444724 | — | — | 1 | 9.22 |
| CHEMBL2420867 | — | — | 1 | 9.22 |
| CHEMBL2420866 | — | — | 1 | 8.92 |
| CHEMBL516047 | — | — | 1 | 8.89 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.70 |
| CHEMBL4746488 | — | — | 1 | 8.60 |
| CHEMBL4753899 | — | — | 1 | 8.55 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.48 |
| CHEMBL4748714 | — | — | 1 | 8.30 |
| CHEMBL512022 | — | — | 1 | 8.07 |
| CHEMBL4756669 | — | — | 1 | 8.07 |
| CHEMBL3604205 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444724 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2420867 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2420866 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL516047 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL492399 | VERUBULIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4746488 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4753899 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4748714 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL512022 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4756669 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3604205 | — | IC50 | = | 16.8 | nM | 7.78 |