Assay Detail
Functional
CHEMBL4714425
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Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.57 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444724 | — | — | 1 | 9.22 |
| CHEMBL2420867 | — | — | 1 | 9.15 |
| CHEMBL516047 | — | — | 1 | 8.96 |
| CHEMBL2420866 | — | — | 1 | 8.92 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.82 |
| CHEMBL4753899 | — | — | 1 | 8.80 |
| CHEMBL4746488 | — | — | 1 | 8.77 |
| CHEMBL4748714 | — | — | 1 | 8.49 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.48 |
| CHEMBL4756669 | — | — | 1 | 8.14 |
| CHEMBL512022 | — | — | 1 | 8.13 |
| CHEMBL3604205 | — | — | 1 | 7.88 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444724 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2420867 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL516047 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2420866 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL492399 | VERUBULIN | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4753899 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4746488 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4748714 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4756669 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL512022 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3604205 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 24.0 | nM | 7.62 |