Assay Detail
Functional
CHEMBL4714428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2420867 | — | — | 1 | 9.00 |
| CHEMBL444724 | — | — | 1 | 8.96 |
| CHEMBL516047 | — | — | 1 | 8.68 |
| CHEMBL2420866 | — | — | 1 | 8.66 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.59 |
| CHEMBL4753899 | — | — | 1 | 8.59 |
| CHEMBL4746488 | — | — | 1 | 8.46 |
| CHEMBL4748714 | — | — | 1 | 8.46 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.14 |
| CHEMBL512022 | — | — | 1 | 7.84 |
| CHEMBL4756669 | — | — | 1 | 7.81 |
| CHEMBL3604205 | — | — | 1 | 7.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2420867 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL444724 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL516047 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2420866 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL492399 | VERUBULIN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4753899 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4746488 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4748714 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL512022 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4756669 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL3604205 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1200.0 | nM | 5.92 |