Assay Detail
Binding
CHEMBL4714430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin assembly preincubated for 15 mins followed by GTP addition measured for 20 mins by turbidimetry-based spectrophotometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.25 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444724 | — | — | 1 | 9.33 |
| CHEMBL516047 | — | — | 1 | 9.32 |
| CHEMBL4746488 | — | — | 1 | 9.19 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444724 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL516047 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4746488 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.73 | nM | 9.14 |