Assay Detail
Binding
CHEMBL4714666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX-2 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.05 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 5.99 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.48 |
| CHEMBL4763530 | — | — | 1 | 5.00 |
| CHEMBL4792690 | — | — | 1 | 4.43 |
| CHEMBL4789884 | — | — | 1 | 4.37 |
| CHEMBL4787114 | — | — | 1 | - |
| CHEMBL4751020 | — | — | 1 | - |
| CHEMBL4763348 | — | — | 1 | - |
| CHEMBL4795293 | — | — | 1 | - |
| CHEMBL4760459 | — | — | 1 | - |
| CHEMBL4753324 | — | — | 1 | - |
| CHEMBL4796831 | — | — | 1 | - |
| CHEMBL4755060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4763530 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4792690 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL4789884 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4787114 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4751020 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4763348 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4795293 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4760459 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4753324 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4796831 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4755060 | — | IC50 | > | 50000.0 | nM | - |