Assay Detail
Binding
CHEMBL4714779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | T-REx-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily T member 1 (CHEMBL4739694) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of the First Orally Available, Selective K1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.53 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741793 | — | — | 1 | 6.21 |
| CHEMBL4763955 | — | — | 1 | 5.94 |
| CHEMBL4754084 | — | — | 1 | 5.90 |
| CHEMBL4788669 | — | — | 1 | 5.52 |
| CHEMBL4786255 | — | — | 1 | 4.84 |
| CHEMBL4750925 | — | — | 1 | 4.77 |
| CHEMBL4793279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741793 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL4763955 | — | IC50 | = | 1143.0 | nM | 5.94 |
| CHEMBL4754084 | — | IC50 | = | 1251.0 | nM | 5.90 |
| CHEMBL4788669 | — | IC50 | = | 3001.0 | nM | 5.52 |
| CHEMBL4786255 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4750925 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL4793279 | — | IC50 | > | 30000.0 | nM | - |