Assay Detail
ADMET
CHEMBL4714841
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Antiproliferative activity against human H1299 cells assessed as inhibition of cell growth incubated for 5 days by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.06 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068896 | — | — | 1 | 5.99 |
| CHEMBL4785949 | — | — | 1 | 5.08 |
| CHEMBL4742889 | — | — | 1 | 4.11 |
| CHEMBL4740775 | — | — | 1 | - |
| CHEMBL4757810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068896 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4785949 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL4742889 | — | IC50 | = | 78400.0 | nM | 4.11 |
| CHEMBL4740775 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL4757810 | — | IC50 | > | 20000.0 | nM | - |