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Assay Detail

CHEMBL4714883

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors.
Lü Z,Li X,Li K,Wang C,Du T,Huang W,Ji M,Li C,Xu F,Xu P,Niu Y
ACS Med Chem Lett (2021) 12 : 696 -703
PubMed 34055214 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.97 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4746255 1 5.57
CHEMBL4752864 1 5.48
CHEMBL1923234 WP 1066 2.0 1 5.38
CHEMBL4759118 1 5.10
CHEMBL4790657 1 5.00
CHEMBL4746874 1 4.96
CHEMBL1241243 1 4.79
CHEMBL407907 1 4.75
CHEMBL1241146 1 4.69
CHEMBL1545 TIZOXANIDE -1.0 1 4.53
CHEMBL1401 NITAZOXANIDE 4.0 1 4.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4746255 IC50 = 2700.0 nM 5.57
CHEMBL4752864 IC50 = 3300.0 nM 5.48
CHEMBL1923234 WP 1066 IC50 = 4200.0 nM 5.38
CHEMBL4759118 IC50 = 7900.0 nM 5.10
CHEMBL4790657 IC50 = 9900.0 nM 5.00
CHEMBL4746874 IC50 = 11100.0 nM 4.96
CHEMBL1241243 IC50 = 16400.0 nM 4.79
CHEMBL407907 IC50 = 17700.0 nM 4.75
CHEMBL1241146 IC50 = 20500.0 nM 4.69
CHEMBL1545 TIZOXANIDE IC50 = 29800.0 nM 4.53
CHEMBL1401 NITAZOXANIDE IC50 = 35000.0 nM 4.46