Assay Detail
Binding
CHEMBL4715072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin) (416 to 766) assessed as using inactive phosphorylated MAP2K1 substrate preincubated for 30 mins measured after 90 mins by DELFIA assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.87 | 9.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740241 | — | — | 1 | 9.99 |
| CHEMBL4776565 | — | — | 1 | 9.92 |
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 9.86 |
| CHEMBL4778419 | — | — | 1 | 9.72 |
| CHEMBL4780060 | — | — | 1 | - |
| CHEMBL4775998 | — | — | 1 | - |
| CHEMBL4778772 | — | — | 1 | - |
| CHEMBL4758903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740241 | — | Ki | = | 0.102 | nM | 9.99 |
| CHEMBL4776565 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL3577124 | LY-3009120 | Ki | = | 0.139 | nM | 9.86 |
| CHEMBL4778419 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL4780060 | — | Ki | < | 0.08 | nM | - |
| CHEMBL4775998 | — | Ki | < | 0.08 | nM | - |
| CHEMBL4778772 | — | Ki | < | 0.08 | nM | - |
| CHEMBL4758903 | — | Ki | < | 0.08 | nM | - |