Assay Detail
Functional
CHEMBL4715076
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Synergistic antiproliferative activity against human A549 cells harboring KRAS mutant assessed as reduction in cell viability in presence of 100 nM cobi-metinib
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.64 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740241 | — | — | 1 | 7.41 |
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 7.34 |
| CHEMBL4758903 | — | — | 1 | 6.86 |
| CHEMBL4775998 | — | — | 1 | 6.83 |
| CHEMBL4778772 | — | — | 1 | 6.73 |
| CHEMBL4778419 | — | — | 1 | 6.43 |
| CHEMBL4776565 | — | — | 1 | 5.95 |
| CHEMBL4780060 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740241 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL3577124 | LY-3009120 | IC50 | = | 45.6 | nM | 7.34 |
| CHEMBL4758903 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL4775998 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4778772 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4778419 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL4776565 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4780060 | — | IC50 | = | 2900.0 | nM | 5.54 |