Assay Detail
Functional
CHEMBL4715591
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Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by celltiter-glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of A-1293102, a Potent and Selective BCL-X Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.81 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3699067 | — | — | 1 | 7.10 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.52 |
| CHEMBL3699066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3699067 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3699066 | — | EC50 | > | 5000.0 | nM | - |