Assay Detail
Binding
CHEMBL4716016
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Inhibition of human S6K1 using KKRNRTLTK peptide substrate by radiometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computer-aided discovery of phenylpyrazole based amides as potent S6K1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.72 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 9.06 |
| CHEMBL480746 | — | — | 1 | 7.80 |
| CHEMBL4799316 | — | — | 1 | 7.25 |
| CHEMBL4779350 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 0.871 | nM | 9.06 |
| CHEMBL480746 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4799316 | — | IC50 | = | 56.7 | nM | 7.25 |
| CHEMBL4779350 | — | IC50 | = | 179.0 | nM | 6.75 |