Assay Detail
Binding
CHEMBL4716075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3kdelta in anti-IgD-induced human whole blood cells assessed as reduction in CD69 expression measured after 6 hrs by immunostaining based flow cytometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790186 | — | — | 1 | 7.72 |
| CHEMBL4754382 | — | — | 1 | 7.71 |
| CHEMBL2216895 | — | — | 1 | 7.66 |
| CHEMBL4784595 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790186 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4754382 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL2216895 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4784595 | — | IC50 | = | 107.0 | nM | 6.97 |