Assay Detail
Binding
CHEMBL4716191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of crizotinib-resistant ALK T1151-L1152 insT mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.96 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743579 | — | — | 1 | 9.48 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 8.77 |
| CHEMBL4782674 | — | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743579 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4782674 | — | IC50 | = | 2.3 | nM | 8.64 |