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Assay Detail

CHEMBL4716829

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition EML4-ALK (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

EML4-ALK (CHEMBL3883330)
Type CHIMERIC PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Michellys PY,Chen B,Jiang T,Jin Y,Lu W,Marsilje TH,Pei W,Uno T,Zhu X,Wu B,Nguyen TN,Bursulaya B,Lee C,Li N,Kim S,Tuntland T,Liu B,Sun F,Steffy A,Hood T
Bioorg Med Chem Lett (2016) 26 : 1090 -1096
PubMed 26750252 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3651854 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3651854 IC50 = 10.0 nM 8.00