Assay Detail
Functional
CHEMBL4716889
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by MTT assay relative to control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 1,3,6-trisubstituted β-carboline derivatives for cytotoxic and anti-leishmanial potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.17 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 5.49 |
| CHEMBL4783669 | — | — | 1 | 5.45 |
| CHEMBL4741892 | — | — | 1 | 5.28 |
| CHEMBL1209196 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL4783669 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL4741892 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1209196 | — | IC50 | = | 35610.0 | nM | 4.45 |