Assay Detail
ADMET
CHEMBL4716892
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Cytotoxicity against human L-132 cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by MTT assay relative to control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L132 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 1,3,6-trisubstituted β-carboline derivatives for cytotoxic and anti-leishmanial potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.16 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 5.78 |
| CHEMBL4783669 | — | — | 1 | 5.49 |
| CHEMBL4741892 | — | — | 1 | 4.95 |
| CHEMBL1209196 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4783669 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4741892 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL1209196 | — | IC50 | = | 39280.0 | nM | 4.41 |