Assay Detail
Functional
CHEMBL4716895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/80/IN/Dd8 promastigotes infected in THP-1 cells assessed as measured after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 1,3,6-trisubstituted β-carboline derivatives for cytotoxic and anti-leishmanial potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.55 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1209196 | — | — | 1 | 5.05 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.92 |
| CHEMBL4750583 | — | — | 1 | 4.63 |
| CHEMBL4783669 | — | — | 1 | 4.17 |
| CHEMBL4755300 | — | — | 1 | 4.00 |
| CHEMBL4756848 | — | — | 1 | - |
| CHEMBL4784796 | — | — | 1 | - |
| CHEMBL4749448 | — | — | 1 | - |
| CHEMBL4741892 | — | — | 1 | - |
| CHEMBL4758843 | — | — | 1 | - |
| CHEMBL4752373 | — | — | 1 | - |
| CHEMBL4757981 | — | — | 1 | - |
| CHEMBL4794215 | — | — | 1 | - |
| CHEMBL4754709 | — | — | 1 | - |
| CHEMBL4798175 | — | — | 1 | - |
| CHEMBL4751270 | — | — | 1 | - |
| CHEMBL4750182 | — | — | 1 | - |
| CHEMBL4747646 | — | — | 1 | - |
| CHEMBL4796926 | — | — | 1 | - |
| CHEMBL4797022 | — | — | 1 | - |
| CHEMBL4776287 | — | — | 1 | - |
| CHEMBL4748456 | — | — | 1 | - |
| CHEMBL4742687 | — | — | 1 | - |
| CHEMBL4788907 | — | — | 1 | - |
| CHEMBL4761253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1209196 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4750583 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL4783669 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4755300 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4756848 | — | IC50 | - | — | - | |
| CHEMBL4784796 | — | IC50 | - | — | - | |
| CHEMBL4749448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4741892 | — | IC50 | - | — | - | |
| CHEMBL4758843 | — | IC50 | - | — | - | |
| CHEMBL4752373 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4757981 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4794215 | — | IC50 | - | — | - | |
| CHEMBL4754709 | — | IC50 | - | — | - | |
| CHEMBL4798175 | — | IC50 | - | — | - | |
| CHEMBL4751270 | — | IC50 | - | — | - | |
| CHEMBL4750182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4747646 | — | IC50 | - | — | - | |
| CHEMBL4796926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4797022 | — | IC50 | - | — | - | |
| CHEMBL4776287 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4748456 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4742687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4788907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4761253 | — | IC50 | > | 100000.0 | nM | - |