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Assay Detail

CHEMBL4717171

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of soya bean 15-LOX by enzyme immunoassay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.
Abdelall EKA,Lamie PF,Ali WAM
Bioorg Med Chem Lett (2016) 26 : 2893 -2899
PubMed 27158139 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.23 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4750876 1 5.55
CHEMBL4778023 1 5.33
CHEMBL4785437 1 5.25
CHEMBL1562610 MECLOFENAMATE SODIUM 4.0 1 5.25
CHEMBL4789752 1 5.24
CHEMBL4798825 1 5.23
CHEMBL4787167 1 5.22
CHEMBL4746534 1 5.21
CHEMBL4789069 1 5.19
CHEMBL4764063 1 5.13
CHEMBL4765087 1 5.13
CHEMBL4764950 1 5.05
CHEMBL118 CELECOXIB 4.0 1 -
CHEMBL25 ASPIRIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4750876 IC50 = 2800.0 nM 5.55
CHEMBL4778023 IC50 = 4700.0 nM 5.33
CHEMBL4785437 IC50 = 5600.0 nM 5.25
CHEMBL1562610 MECLOFENAMATE SODIUM IC50 = 5640.0 nM 5.25
CHEMBL4789752 IC50 = 5800.0 nM 5.24
CHEMBL4798825 IC50 = 5900.0 nM 5.23
CHEMBL4787167 IC50 = 6020.0 nM 5.22
CHEMBL4746534 IC50 = 6220.0 nM 5.21
CHEMBL4789069 IC50 = 6400.0 nM 5.19
CHEMBL4764063 IC50 = 7400.0 nM 5.13
CHEMBL4765087 IC50 = 7400.0 nM 5.13
CHEMBL4764950 IC50 = 8900.0 nM 5.05
CHEMBL118 CELECOXIB IC50 - -
CHEMBL25 ASPIRIN IC50 - -