Assay Detail
Functional
CHEMBL4717200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MES-SA/DX5 cells transfected with mCherry fluorescent protein assessed as inhibition of cell proliferation incubated for 72 hrs by fluorescent assay
79
Total Activities
48
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 77 | 5.92 | 7.59 |
| pIC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631726 | — | — | 2 | 7.59 |
| CHEMBL4743024 | — | — | 1 | 7.25 |
| CHEMBL3250265 | — | — | 2 | 7.24 |
| CHEMBL4776481 | — | — | 2 | 7.23 |
| CHEMBL1631725 | — | — | 2 | 7.21 |
| CHEMBL4789856 | — | — | 2 | 7.08 |
| CHEMBL1631724 | — | — | 2 | 7.06 |
| CHEMBL4760307 | — | — | 2 | 6.86 |
| CHEMBL4755712 | — | — | 2 | 6.85 |
| CHEMBL4759207 | — | — | 2 | 6.66 |
| CHEMBL4761397 | — | — | 2 | 6.54 |
| CHEMBL4760526 | — | — | 2 | 6.46 |
| CHEMBL4754848 | — | — | 2 | 6.40 |
| CHEMBL4757610 | — | — | 2 | 6.37 |
| CHEMBL4584496 | — | — | 2 | 6.25 |
| CHEMBL4788932 | — | — | 2 | 6.25 |
| CHEMBL4795083 | — | — | 2 | 6.16 |
| CHEMBL4785334 | — | — | 1 | 5.73 |
| CHEMBL4747797 | — | — | 1 | 5.73 |
| CHEMBL3325577 | — | — | 2 | 5.73 |
| CHEMBL2285982 | — | — | 1 | 5.71 |
| CHEMBL4755683 | — | — | 1 | 5.68 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | 5.60 |
| CHEMBL522087 | — | — | 1 | 5.60 |
| CHEMBL4756990 | — | — | 2 | 5.59 |
| CHEMBL4794774 | — | — | 2 | 5.56 |
| CHEMBL2004141 | — | — | 2 | 5.51 |
| CHEMBL1762442 | — | — | 1 | 5.49 |
| CHEMBL4776039 | — | — | 2 | 5.46 |
| CHEMBL4791886 | — | — | 2 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631726 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL1631726 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4743024 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3250265 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL4776481 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4776481 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL1631725 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL1631725 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3250265 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4789856 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL1631724 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL1631724 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4789856 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4760307 | — | IC50 | = | 138.04 | nM | 6.86 |
| CHEMBL4755712 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL4760307 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4755712 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4759207 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4759207 | — | IC50 | = | 234.42 | nM | 6.63 |
| CHEMBL4761397 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4761397 | — | IC50 | = | 295.12 | nM | 6.53 |
| CHEMBL4760526 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL4760526 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4754848 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4754848 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4757610 | — | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL4757610 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4788932 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL4584496 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL4584496 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4795083 | — | IC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4795083 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4788932 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4785334 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4747797 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3325577 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL2285982 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3325577 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4755683 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 2523.0 | nM | 5.60 |
| CHEMBL522087 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL4756990 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL4756990 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4794774 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL4794774 | — | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL2004141 | — | IC50 | = | 3090.3 | nM | 5.51 |
| CHEMBL1762442 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL2004141 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL4776039 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL4791886 | — | IC50 | = | 3548.13 | nM | 5.45 |