Assay Detail
Functional
CHEMBL4717201
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Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
42
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.64 | 7.43 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631726 | — | — | 2 | 7.43 |
| CHEMBL4789856 | — | — | 2 | 6.47 |
| CHEMBL4759207 | — | — | 2 | 6.45 |
| CHEMBL4791886 | — | — | 2 | 6.21 |
| CHEMBL2004141 | — | — | 2 | 6.19 |
| CHEMBL3250265 | — | — | 2 | 6.16 |
| CHEMBL4788932 | — | — | 2 | 6.14 |
| CHEMBL4794774 | — | — | 2 | 5.99 |
| CHEMBL4755683 | — | — | 2 | 5.91 |
| CHEMBL4756990 | — | — | 2 | 5.72 |
| CHEMBL4747797 | — | — | 2 | 5.48 |
| CHEMBL1762442 | — | — | 2 | 5.38 |
| CHEMBL4785334 | — | — | 2 | 5.30 |
| CHEMBL522087 | — | — | 2 | 5.21 |
| CHEMBL504574 | — | — | 2 | 5.12 |
| CHEMBL1915697 | — | — | 2 | 5.11 |
| CHEMBL4789302 | — | — | 2 | 5.10 |
| CHEMBL4763189 | — | — | 2 | 4.86 |
| CHEMBL4743469 | — | — | 2 | 4.80 |
| CHEMBL4781807 | — | — | 2 | 4.69 |
| CHEMBL4763977 | — | — | 1 | 4.26 |
| CHEMBL4794964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631726 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL1631726 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL4789856 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4759207 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL4759207 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4789856 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL4791886 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2004141 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2004141 | — | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL3250265 | — | IC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4788932 | — | IC50 | = | 724.44 | nM | 6.14 |
| CHEMBL4788932 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4791886 | — | IC50 | = | 933.25 | nM | 6.03 |
| CHEMBL3250265 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4794774 | — | IC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL4794774 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4755683 | — | IC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL4755683 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4756990 | — | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL4756990 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4747797 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL4747797 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL1762442 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL1762442 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4785334 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4785334 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL522087 | — | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL522087 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL504574 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL1915697 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL504574 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL4789302 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4789302 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL1915697 | — | IC50 | = | 8196.0 | nM | 5.09 |
| CHEMBL4763189 | — | IC50 | = | 13803.84 | nM | 4.86 |
| CHEMBL4763189 | — | IC50 | = | 14290.0 | nM | 4.84 |
| CHEMBL4743469 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4743469 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL4781807 | — | IC50 | = | 20580.0 | nM | 4.69 |
| CHEMBL4781807 | — | IC50 | = | 20417.38 | nM | 4.69 |
| CHEMBL4763977 | — | IC50 | = | 54954.09 | nM | 4.26 |
| CHEMBL4794964 | — | pIC50 | - | — | - |