Assay Detail
Binding
CHEMBL4717438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain FTase using 3H-farnesyl diphosphate as substrate incubated for 30 mins by beta-plate counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.90 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103955 | CHAETOMELLIC ACID A | — | 1 | 7.26 |
| CHEMBL4745820 | — | — | 1 | 7.00 |
| CHEMBL4794392 | — | — | 1 | 7.00 |
| CHEMBL335691 | — | — | 1 | 6.82 |
| CHEMBL100815 | CHAETOMELLIC ACID B | — | 1 | 6.73 |
| CHEMBL4749161 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103955 | CHAETOMELLIC ACID A | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4745820 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4794392 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL335691 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL100815 | CHAETOMELLIC ACID B | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4749161 | — | IC50 | = | 250.0 | nM | 6.60 |