Assay Detail
Functional
CHEMBL4717658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiarrhythmic activity in 50 Hz sinusoidal alternating current-induced guinea pig left atrium arrhythmias model assessed as increase in threshold of ac-arrhythmia measured for every 30 mins relative to control
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Left cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.42 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4742143 | — | — | 1 | 6.37 |
| CHEMBL4741603 | — | — | 1 | 5.68 |
| CHEMBL4764860 | — | — | 1 | 5.36 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | 4.0 | 1 | 4.94 |
| CHEMBL4746834 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4742143 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4741603 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4764860 | — | EC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4746834 | — | EC50 | = | 18400.0 | nM | 4.74 |