Assay Detail
ADMET
CHEMBL4717666
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Negative inotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in developed tension
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Right cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.09 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764860 | — | — | 1 | 7.18 |
| CHEMBL4741603 | — | — | 1 | 5.99 |
| CHEMBL4742143 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764860 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4741603 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4742143 | — | EC50 | = | 8200.0 | nM | 5.09 |