Assay Detail
Functional
CHEMBL4717689
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Inhibition of glucose-induced insulin secretion in Wistar rat pancreatic islets incubated for 90 mins in presence of 16.7 mM glucose by radioimmunological assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pancreatic islet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.62 | 6.62 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102380 | — | — | 2 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102380 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4102380 | — | Inhibition | - | % | - |