Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4718228

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cruzipain (CHEMBL3563)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

New 1,3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi.
de Moraes Gomes PAT,de Oliveira Barbosa M,Farias Santiago E,de Oliveira Cardoso MV,Capistrano Costa NT,Hernandes MZ,Moreira DRM,da Silva AC,Dos Santos TAR,Pereira VRA,Brayner Dos Santosd FA,do Nascimento Pereira GA,Ferreira RS,Leite ACL
Eur J Med Chem (2016) 121 : 387 -398
PubMed 27295485 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.19 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313679 1 7.40
CHEMBL4744510 1 6.29
CHEMBL3787543 1 5.42
CHEMBL4782594 1 5.02
CHEMBL4747507 1 4.95
CHEMBL3787688 1 4.84
CHEMBL4746565 1 4.82
CHEMBL4744489 1 4.78
CHEMBL3785603 1 4.72
CHEMBL4743580 1 4.49
CHEMBL3785430 1 4.35
CHEMBL4789584 1 -
CHEMBL4763953 1 -
CHEMBL4748457 1 -
CHEMBL4796716 1 -
CHEMBL3785627 1 -
CHEMBL328234 1 -
CHEMBL88307 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313679 IC50 = 40.0 nM 7.40
CHEMBL4744510 IC50 = 510.0 nM 6.29
CHEMBL3787543 IC50 = 3800.0 nM 5.42
CHEMBL4782594 IC50 = 9500.0 nM 5.02
CHEMBL4747507 IC50 = 11300.0 nM 4.95
CHEMBL3787688 IC50 = 14600.0 nM 4.84
CHEMBL4746565 IC50 = 15100.0 nM 4.82
CHEMBL4744489 IC50 = 16500.0 nM 4.78
CHEMBL3785603 IC50 = 19200.0 nM 4.72
CHEMBL4743580 IC50 = 32700.0 nM 4.49
CHEMBL3785430 IC50 = 44600.0 nM 4.35
CHEMBL4789584 IC50 - -
CHEMBL4763953 IC50 - -
CHEMBL4748457 IC50 - -
CHEMBL4796716 IC50 - -
CHEMBL3785627 IC50 - -
CHEMBL328234 IC50 - -
CHEMBL88307 IC50 - -