Assay Detail
Binding
CHEMBL4718402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of cathepsin B (unknown origin) using varying level of RR-AMC as substrate by Lineweaver-Burk plot analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.15 | 5.32 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756611 | — | — | 2 | 5.32 |
| CHEMBL4740912 | — | — | 2 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756611 | — | Ki | = | 4740.0 | nM | 5.32 |
| CHEMBL4740912 | — | Ki | = | 10610.0 | nM | 4.97 |
| CHEMBL4756611 | — | Inhibition | - | % | - | |
| CHEMBL4740912 | — | Inhibition | - | % | - |