Assay Detail
Functional
CHEMBL4718404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.77 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 8.20 |
| CHEMBL4799044 | — | — | 1 | 6.22 |
| CHEMBL4783733 | — | — | 1 | 6.16 |
| CHEMBL4780890 | — | — | 1 | 6.05 |
| CHEMBL4797507 | — | — | 1 | 6.05 |
| CHEMBL4787043 | — | — | 1 | 5.85 |
| CHEMBL4743751 | — | — | 1 | 5.82 |
| CHEMBL4760529 | — | — | 1 | 5.68 |
| CHEMBL4798793 | — | — | 1 | 5.58 |
| CHEMBL3633234 | — | — | 1 | 5.54 |
| CHEMBL4792497 | — | — | 1 | 5.54 |
| CHEMBL4743607 | — | — | 1 | 5.44 |
| CHEMBL4795367 | — | — | 1 | 5.25 |
| CHEMBL4740826 | — | — | 1 | 5.07 |
| CHEMBL4796022 | — | — | 1 | 4.98 |
| CHEMBL4747045 | — | — | 1 | 4.93 |
| CHEMBL4764631 | — | — | 1 | - |
| CHEMBL4790881 | — | — | 1 | - |
| CHEMBL4776511 | — | — | 1 | - |
| CHEMBL4757919 | — | — | 1 | - |
| CHEMBL4755789 | — | — | 1 | - |
| CHEMBL4763218 | — | — | 1 | - |
| CHEMBL4753728 | — | — | 1 | - |
| CHEMBL4789370 | — | — | 1 | - |
| CHEMBL4763118 | — | — | 1 | - |
| CHEMBL4740869 | — | — | 1 | - |
| CHEMBL4755984 | — | — | 1 | - |
| CHEMBL4751796 | — | — | 1 | - |
| CHEMBL4760184 | — | — | 1 | - |
| CHEMBL4793845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4799044 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4783733 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4780890 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4797507 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4787043 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4743751 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4760529 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4798793 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3633234 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4792497 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4743607 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4795367 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4740826 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4796022 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4747045 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4747119 | — | IC50 | - | — | - | |
| CHEMBL4757025 | — | IC50 | - | — | - | |
| CHEMBL4800496 | — | IC50 | - | — | - | |
| CHEMBL4783249 | — | IC50 | - | — | - | |
| CHEMBL4752725 | — | IC50 | - | — | - | |
| CHEMBL4747762 | — | IC50 | - | — | - | |
| CHEMBL4793845 | — | IC50 | - | — | - | |
| CHEMBL4760184 | — | IC50 | - | — | - | |
| CHEMBL4751796 | — | IC50 | - | — | - | |
| CHEMBL4755984 | — | IC50 | - | — | - | |
| CHEMBL4740869 | — | IC50 | - | — | - | |
| CHEMBL4763118 | — | IC50 | - | — | - | |
| CHEMBL4789370 | — | IC50 | - | — | - | |
| CHEMBL4753728 | — | IC50 | - | — | - | |
| CHEMBL4763218 | — | IC50 | - | — | - | |
| CHEMBL4755789 | — | IC50 | - | — | - | |
| CHEMBL4757919 | — | IC50 | - | — | - | |
| CHEMBL4776511 | — | IC50 | - | — | - | |
| CHEMBL4790881 | — | IC50 | - | — | - | |
| CHEMBL4764631 | — | IC50 | - | — | - |