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Assay Detail

CHEMBL4718606

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity assessed as DPPH radical scavenging activity incubated for 60 mins in absence of light
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.
Vázquez-Jiménez L,Garrido M,Miceli M,Prats E,Ferrer-Montiel A,Teixidó M,Jimeno C,Messeguer A
Eur J Med Chem (2016) 123 : 788 -802
PubMed 27541262 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.86 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4747699 1 5.16
CHEMBL4747354 1 5.08
CHEMBL4799132 1 4.98
CHEMBL4793012 1 4.88
CHEMBL4744943 1 4.85
CHEMBL4755403 1 4.85
CHEMBL4760848 1 4.84
CHEMBL4793596 1 4.83
CHEMBL4763677 1 4.83
CHEMBL4797546 1 4.82
CHEMBL4756734 1 4.81
CHEMBL153 TROLOX 1 4.80
CHEMBL4790338 1 4.79
CHEMBL4744769 1 4.76
CHEMBL4740326 1 4.72
CHEMBL4793823 1 4.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4747699 IC50 = 6900.0 nM 5.16
CHEMBL4747354 IC50 = 8400.0 nM 5.08
CHEMBL4799132 IC50 = 10500.0 nM 4.98
CHEMBL4793012 IC50 = 13100.0 nM 4.88
CHEMBL4744943 IC50 = 14100.0 nM 4.85
CHEMBL4755403 IC50 = 14100.0 nM 4.85
CHEMBL4760848 IC50 = 14300.0 nM 4.84
CHEMBL4793596 IC50 = 14900.0 nM 4.83
CHEMBL4763677 IC50 = 14700.0 nM 4.83
CHEMBL4797546 IC50 = 15000.0 nM 4.82
CHEMBL4756734 IC50 = 15500.0 nM 4.81
CHEMBL153 TROLOX IC50 = 15700.0 nM 4.80
CHEMBL4790338 IC50 = 16200.0 nM 4.79
CHEMBL4744769 IC50 = 17300.0 nM 4.76
CHEMBL4740326 IC50 = 19100.0 nM 4.72
CHEMBL4793823 IC50 = 19600.0 nM 4.71