Assay Detail
Functional
CHEMBL4718769
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Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82 amastigotes measured after 72 hrs by alamar blue dye based fluorimetry analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.77 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797262 | — | — | 1 | 5.00 |
| CHEMBL1459740 | — | — | 1 | 4.96 |
| CHEMBL4758947 | — | — | 1 | 4.92 |
| CHEMBL3800137 | — | — | 1 | 4.77 |
| CHEMBL1872842 | — | — | 1 | 4.60 |
| CHEMBL2094559 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797262 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1459740 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4758947 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3800137 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1872842 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2094559 | — | IC50 | = | 46000.0 | nM | 4.34 |