Assay Detail

CHEMBL4718833

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Functional

Antiproliferative activity against human C-33A cells incubated for 72 hrs by ATPlite luminescence assay

ChEMBL ↗

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Target

C-33-A (CHEMBL2366313) ↗

Open DB target context

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C-33-A (CHEMBL2366313) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target C-33-A

CHEMBL2366313

Anchored from Assay target.

Protein identity C-33-A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	C-33-A
Confidence	1 — Organism
Curated By	Autocuration

Target

C-33-A (CHEMBL2366313) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors.

Han J,Henriksen S,Nørsett KG,Sundby E,Hoff BH
Eur J Med Chem (2016) 124 : 583 -607
PubMed 27614407 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.11	6.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4780286	—	—	1	6.16
CHEMBL553	ERLOTINIB	4.0	1	6.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4780286	—	IC50	=	700.0	nM	6.16
CHEMBL553	ERLOTINIB	IC50	=	900.0	nM	6.05