Assay Detail
Functional
CHEMBL4718834
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Antiproliferative activity against human CAL27 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.73 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.89 |
| CHEMBL4780286 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4780286 | — | IC50 | = | 2700.0 | nM | 5.57 |