Assay Detail
Binding
CHEMBL4718956
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Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pterin-7-carboxamides as a new class of aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.70 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.18 |
| CHEMBL4777280 | — | — | 1 | 5.71 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.70 |
| CHEMBL4745089 | — | — | 1 | 5.40 |
| CHEMBL4762839 | — | — | 1 | 4.93 |
| CHEMBL4744462 | — | — | 1 | 4.91 |
| CHEMBL4745506 | — | — | 1 | 4.76 |
| CHEMBL4789697 | — | — | 1 | 4.60 |
| CHEMBL4745461 | — | — | 1 | 4.59 |
| CHEMBL1738820 | — | — | 1 | 4.58 |
| CHEMBL4746973 | — | — | 1 | 4.54 |
| CHEMBL4787662 | — | — | 1 | 4.38 |
| CHEMBL4784707 | — | — | 1 | 4.37 |
| CHEMBL4785735 | — | — | 1 | 4.34 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | 4.28 |
| CHEMBL4750668 | — | — | 1 | 4.25 |
| CHEMBL4761144 | — | — | 1 | 4.21 |
| CHEMBL4799115 | — | — | 1 | 4.17 |
| CHEMBL4742660 | — | — | 1 | 4.16 |
| CHEMBL4753734 | — | — | 1 | 4.14 |
| CHEMBL4757375 | — | — | 1 | 4.08 |
| CHEMBL4793705 | — | — | 1 | 4.01 |
| CHEMBL566727 | PTERIN-6-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL4789279 | — | — | 1 | - |
| CHEMBL4764277 | — | — | 1 | - |
| CHEMBL4795565 | — | — | 1 | - |
| CHEMBL4793992 | — | — | 1 | - |
| CHEMBL4741969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 66.5 | nM | 7.18 |
| CHEMBL4777280 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL266497 | SORBINIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4745089 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4762839 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4744462 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4745506 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4789697 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4745461 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1738820 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4746973 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4787662 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL4784707 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL4785735 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1622 | FOLIC ACID | IC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL4750668 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL4761144 | — | IC50 | = | 61700.0 | nM | 4.21 |
| CHEMBL4799115 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL4742660 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4753734 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4757375 | — | IC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL4793705 | — | IC50 | = | 97200.0 | nM | 4.01 |
| CHEMBL566727 | PTERIN-6-CARBOXYLIC ACID | IC50 | - | — | - | |
| CHEMBL4789279 | — | IC50 | = | 216000.0 | nM | - |
| CHEMBL4764277 | — | IC50 | = | 194000.0 | nM | - |
| CHEMBL4795565 | — | IC50 | = | 278000.0 | nM | - |
| CHEMBL4793992 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4741969 | — | IC50 | = | 580000.0 | nM | - |