Assay Detail
Functional
CHEMBL4719604
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Antiviral activity against wild-type HCV J6/JFH/JC1 infected in human Huh7.5 cells assessed as inhibition of viral replication measured after 72 hrs by qRT-PCR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh7.5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.71 | 10.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.75 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.70 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 7.40 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.19 |
| CHEMBL3596977 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.01767 | nM | 10.75 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL501849 | SIMEPREVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3596977 | — | EC50 | = | 3030.0 | nM | 5.52 |