Assay Detail
Binding
CHEMBL4721894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as receptor transactivation by luciferase reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.42 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755323 | — | — | 1 | 9.52 |
| CHEMBL4649683 | — | — | 1 | 9.40 |
| CHEMBL4640515 | — | — | 1 | 9.15 |
| CHEMBL4739884 | — | — | 1 | 9.10 |
| CHEMBL4743546 | — | — | 1 | 9.00 |
| CHEMBL4740848 | — | — | 1 | 8.92 |
| CHEMBL4741090 | — | — | 1 | 8.89 |
| CHEMBL4744325 | — | — | 1 | 8.82 |
| CHEMBL4757948 | — | — | 1 | 8.43 |
| CHEMBL4764454 | — | — | 1 | 8.35 |
| CHEMBL4784739 | — | — | 1 | 8.26 |
| CHEMBL4740551 | — | — | 1 | 8.08 |
| CHEMBL4757859 | — | — | 1 | 8.02 |
| CHEMBL4755428 | — | — | 1 | 7.87 |
| CHEMBL4739905 | — | — | 1 | 7.70 |
| CHEMBL3958704 | — | — | 1 | 7.43 |
| CHEMBL4748470 | — | — | 1 | 7.41 |
| CHEMBL4753405 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755323 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4649683 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4640515 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4739884 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4743546 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4740848 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4741090 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4744325 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4757948 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4764454 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4784739 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4740551 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4757859 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4755428 | — | EC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4739905 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3958704 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4748470 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4753405 | — | EC50 | = | 59.0 | nM | 7.23 |