Assay Detail
ADMET
CHEMBL4722531
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Binding affinity to human MetAP1 expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of quinoline-carbaldehyde derivatives as novel inhibitors for leishmanial methionine aminopeptidase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.70 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740594 | — | — | 1 | 9.82 |
| CHEMBL4755128 | — | — | 1 | 7.45 |
| CHEMBL4759563 | — | — | 1 | 7.07 |
| CHEMBL4743733 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740594 | — | Kd | = | 0.152 | nM | 9.82 |
| CHEMBL4755128 | — | Kd | = | 35.3 | nM | 7.45 |
| CHEMBL4759563 | — | Kd | = | 85.2 | nM | 7.07 |
| CHEMBL4743733 | — | Kd | = | 361.0 | nM | 6.44 |