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Assay Detail

CHEMBL4723150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against SARS-CoV BJ-001 infected in African green monkey Vero E6 cells assessed as reduction in virus induced cytopathic effect incubated for 72 hrs by MTS/phenazine methosulfate method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Severe acute respiratory syndrome-related coronavirus
Cell Type Vero C1008
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV (CHEMBL4303836)
Type ORGANISM
Organism Severe acute respiratory syndrome-related coronavirus

Publication

Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Choudhry N,Zhao X,Xu D,Zanin M,Chen W,Yang Z,Chen J
J Med Chem (2020) 63 : 13205 -13227
PubMed 32845145 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.80 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL400092 LYCORINE 1 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL400092 LYCORINE IC50 = 15.7 nM 7.80