Assay Detail
Binding
CHEMBL4723172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV N-terminal 6His-tagged TEV-fused papain-like protease expressed in Escherichia coli BL21(DE3) cells using Z-RLRGG-AMC as substrate by fluorescence method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.26 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751323 | — | — | 1 | 5.38 |
| CHEMBL1231518 | — | — | 1 | 5.38 |
| CHEMBL512693 | NEOBAVAISOFLAVONE | — | 1 | 5.38 |
| CHEMBL4783450 | — | — | 1 | 5.38 |
| CHEMBL4064323 | — | — | 1 | 5.38 |
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 5.14 |
| CHEMBL3792825 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751323 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1231518 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL512693 | NEOBAVAISOFLAVONE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4783450 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4064323 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL253467 | ISOBAVACHALCONE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3792825 | — | IC50 | = | 15800.0 | nM | 4.80 |