Assay Detail
Functional
CHEMBL4723186
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Antiviral activity against SARS-CoV infected in African green monkey Vero E6 cells assessed as reduction in viral replication by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.59 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223643 | VALINOMYCIN | — | 1 | 6.07 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.47 |
| CHEMBL507233 | ESCIN IA | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223643 | VALINOMYCIN | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL772 | RESERPINE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL507233 | ESCIN IA | IC50 | = | 6000.0 | nM | 5.22 |