Assay Detail
Functional
CHEMBL4723223
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In vivo inhibition of FGFR4 in mouse xenografted with human Hep3B cells assessed as decrease in FGFR4 phosphorylation
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 1 | - | - |
| IC50 | 1 | 8.54 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973674 | — | — | 2 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973674 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3973674 | — | IC90 | = | 72.0 | nM | - |