Assay Detail
Binding
CHEMBL4723295
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Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 7.58 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796410 | — | — | 1 | 8.60 |
| CHEMBL4781882 | — | — | 1 | 8.54 |
| CHEMBL4790514 | — | — | 1 | 8.43 |
| CHEMBL3946444 | — | — | 1 | 8.42 |
| CHEMBL4752511 | — | — | 1 | 8.41 |
| CHEMBL3973674 | — | — | 1 | 8.37 |
| CHEMBL4745780 | — | — | 1 | 8.35 |
| CHEMBL3968334 | — | — | 1 | 8.35 |
| CHEMBL4791610 | — | — | 1 | 8.32 |
| CHEMBL4784243 | — | — | 1 | 8.30 |
| CHEMBL4758510 | — | — | 1 | 8.30 |
| CHEMBL4745615 | — | — | 1 | 8.28 |
| CHEMBL4787060 | — | — | 1 | 8.24 |
| CHEMBL4754106 | — | — | 1 | 8.24 |
| CHEMBL4784921 | — | — | 1 | 8.23 |
| CHEMBL4786195 | — | — | 1 | 8.21 |
| CHEMBL4764394 | — | — | 1 | 8.15 |
| CHEMBL4778828 | — | — | 1 | 8.15 |
| CHEMBL3972276 | — | — | 1 | 8.12 |
| CHEMBL4284069 | — | — | 1 | 8.08 |
| CHEMBL3912070 | — | — | 1 | 8.06 |
| CHEMBL3983290 | — | — | 1 | 8.06 |
| CHEMBL4742811 | — | — | 1 | 8.02 |
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 8.00 |
| CHEMBL4789692 | — | — | 1 | 7.96 |
| CHEMBL4781381 | — | — | 1 | 7.92 |
| CHEMBL4106685 | — | — | 1 | 7.92 |
| CHEMBL4756889 | — | — | 1 | 7.89 |
| CHEMBL3916036 | — | — | 1 | 7.85 |
| CHEMBL3955498 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796410 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4781882 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4790514 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3946444 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4752511 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3973674 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4745780 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3968334 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4791610 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4784243 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4758510 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4745615 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4787060 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4754106 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4784921 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4786195 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4764394 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4778828 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3972276 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4284069 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3912070 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3983290 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4742811 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3828009 | LY-2874455 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4789692 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4781381 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4106685 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4756889 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3916036 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3955498 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3904499 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4764678 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4780066 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3925900 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3908044 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4777580 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4759211 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3951479 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4758832 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3950552 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4744460 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3940572 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4752290 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3904341 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3973588 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3964830 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3966721 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4779862 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4287768 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3905155 | — | IC50 | = | 42.0 | nM | 7.38 |