Assay Detail
Functional
CHEMBL4723392
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.75 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 2 | 6.43 |
| CHEMBL2165736 | — | — | 2 | 6.00 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2165736 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2165736 | — | IC50 | = | 1023.29 | nM | 5.99 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 75000.0 | nM | 4.12 |