Assay Detail
Functional
CHEMBL4723447
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Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.28 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.49 |
| CHEMBL2165736 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | IC50 | = | 323.59 | nM | 6.49 |
| CHEMBL2165736 | — | IC50 | = | 851.14 | nM | 6.07 |